abstract：BACKGROUND:Aim of this study was to evaluate the effect of the telmisartan-amlodipine combination at different doses on urinary albumin excretion rate (UAER) in hypertensive diabetic patients with microalbuminuria. METHODS:After a 2-week placebo period, 300 hypertensive patients with type 2 diabetes and microalbuminur...

journal_title：American journal of hypertension

authors： Fogari R,Derosa G,Zoppi A,Preti P,Lazzari P,Destro M,Fogari E,Rinaldi A,Mugellini A

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND:In the hypertensive heart, epicardial arteries are not enlarged, despite increased total coronary flow related to augmented cardiac workload, wall stress, and left ventricular (LV) mass. The aims of this study were to assess the impact of different hemodynamic factors and LV mass on baseline left main corona...

journal_title：American journal of hypertension

authors： Kozakova M,Paterni M,Bartolomucci F,Morizzo C,Rossi G,Galetta F,Palombo C

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:The independent prognostic value of daytime and night-time blood pressure (BP) variability estimated by noninvasive 24-h BP monitoring is unclear. METHODS:We followed 2649 initially untreated subjects with essential hypertension for up to 16 years (mean, 6). Variability of BP was estimated by the standard d...

journal_title：American journal of hypertension

authors： Verdecchia P,Angeli F,Gattobigio R,Rapicetta C,Reboldi G

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND:Circulating blood levels of human urotensin II (U-II), the most potent vasoconstrictor peptide identified to date, are increased in patients with essential hypertension. Our previous studies showed that U-II accelerates human macrophage foam cell formation and vascular smooth muscle cell proliferation, sugge...

journal_title：American journal of hypertension

authors： Suguro T,Watanabe T,Ban Y,Kodate S,Misaki A,Hirano T,Miyazaki A,Adachi M

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND:The aims of this study were to document the presence of phospholipase C (PLC) isozymes beta(1), gamma(1), and delta(1) in freshly isolated renal glomeruli and resistance vessels, to compare their expression and activity to that in aorta, and to contrast values between 6-week-old Wistar-Kyoto (WKY) controls a...

journal_title：American journal of hypertension

authors： Peng Z,Dang A,Arendshorst WJ

更新日期：2007-01-01 00:00:00

abstract：:The syndrome of apparent mineralocorticoid excess (AME) is characterized by persistent hypertension and hypokalemia, which is caused by impaired inactivation of cortisol (F) to cortisone (E). The thyroid hormone has been known to influence the F to E conversion leading to efficacious inactivation of F into E. However,...

journal_title：American journal of hypertension

authors： Inagaki K,Otsuka F,Otani H,Sato C,Miyoshi T,Ogura T,Makino H

更新日期：2007-01-01 00:00:00

abstract：:Onset of diabetes increases plasma renin activity (PRA) and glomerular filtration rate (GFR), but blood pressure (BP) is normal. In this study, a 70% surgical reduction in kidney mass (RK) was used to decrease baseline GFR and to prevent hyperfiltration during diabetes, and angiotensin converting enzyme inhibitors (AC...

journal_title：American journal of hypertension

authors： Rojas M,Bell TD,Sturgis LC,Springfield V,Janardhanan R,Fleming C,Brands MW

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:High blood pressure (BP) is associated with the presence and severity of subclinical disease. Less is known about associations between normal levels of BP and various measures of subclinical disease. METHODS:The Multi-Ethnic Study of Atherosclerosis (MESA) enrolled 6814 participants free of clinical cardiov...

journal_title：American journal of hypertension

authors： Psaty BM,Arnold AM,Olson J,Saad MF,Shea S,Post W,Burke GL

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:Endothelium-dependent vascular relaxation is impaired in various disease states including hypertension. METHODS:We investigated whether a single bolus dose of clofibrate could rapidly reverse saline-induced endothelial dysfunction, in vivo, in salt-loaded Sprague-Dawley (S-D) rats. S-D rats, 5 weeks of age,...

journal_title：American journal of hypertension

authors： Sankaralingam S,Desai KM,Wilson TW

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:Sympathetic activation occurs in hypertension (HT) and after acute myocardial infarction (AMI) and is related to greater cardiovascular risk. Also, AMI in patients with HT (AMI-HT) carries greater risk than that in normal subjects (AMI-NT). We therefore planned to determine whether the sympathetic activation...

journal_title：American journal of hypertension

authors： Hogarth AJ,Mackintosh AF,Mary DA

更新日期：2006-10-01 00:00:00

abstract：:Cigarette smoking, an established cardiovascular (CV) disease risk factor, is known to impair pulsatile arterial function. However, information is scant in this regard on asymptomatic younger adult former smokers. As part of the Bogalusa Heart Study, the pulsatile arterial function was examined noninvasively in 278 no...

journal_title：American journal of hypertension

authors： Li H,Srinivasan SR,Berenson GS

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:We postulated that acute hypoxemia increases susceptibility to orthostatic hypotension by increasing the sensitivity of cardiovascular baroreceptors. METHODS:Hemodynamics were measured noninvasively in 17 healthy, normotensive subjects while being subjected to decreasing venous return by exposure to lower b...

journal_title：American journal of hypertension

authors： Fox WC,Watson R,Lockette W

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:It is not clear which educational strategy is most effective in helping patients to change their lifestyles. This study compared the efficacy of two different educational models on reducing blood pressure (BP). METHODS:This was a randomized controlled trial in ambulatory hypertensive patients >65 years of a...

journal_title：American journal of hypertension

authors： Figar S,Galarza C,Petrlik E,Hornstein L,Rodríguez Loria G,Waisman G,Rada M,Soriano ER,de Quirós FG

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:We reported that insulin modestly stimulates NAD(P)H oxidase activity in cultured rat vascular smooth muscle cells (VSMC) and synergistically stimulates enzyme activity with angiotensin II (Ang II), leading to synergistic stimulation of VSMC migration. The aim of this study was to determine the mechanism of ...

journal_title：American journal of hypertension

authors： Yang M,Kahn AM

更新日期：2006-06-01 00:00:00

abstract：:The metabolic syndrome is a cluster of disturbances such as type 2 diabetes mellitus, hypertension, central obesity, dyslipidemia, and others for which insulin resistance and compensatory hyperinsulinemia have been proposed to be the underlying disorders. Several possible mechanisms linking insulin resistance and comp...

journal_title：American journal of hypertension

authors： Sarafidis PA,Lasaridis AN

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:Family history of hypertension is a primary predictor of high blood pressure (BP). This study attempted to determine whether there is a gradual increase in BP between individuals with two hypertensive parents, one hypertensive parent, and normotensive parents and whether this increase is apparent with both a...

journal_title：American journal of hypertension

authors： Goldstein IB,Shapiro D,Guthrie D

更新日期：2006-05-01 00:00:00

abstract：:Recent findings related to the renin-angiotensin system have provided a more elaborated understanding of the pathophysiology of hypertension and kidney diseases. These findings have led to unique concepts and issues regarding the intrarenal renin-angiotensin system. Angiotensinogen is the only known substrate for reni...

journal_title：American journal of hypertension

authors： Kobori H,Ozawa Y,Suzaki Y,Prieto-Carrasquero MC,Nishiyama A,Shoji T,Cohen EP,Navar LG

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND:Expression of matrix metalloproteinase (MMP) has been shown in aortic dissection and aneurysms indicating increased proteolysis compared with the normal aorta. However, its role in the development of aortic root dilatation has not been studied. We therefore attempted to determine the relationship between aor...

journal_title：American journal of hypertension

authors： Karakaya O,Barutcu I,Esen AM,Dogan S,Saglam M,Karapinar H,Akgun T,Karavelioglu Y,Esen O,Ozdemir N,Turkmen S,Kaymaz C

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND:Carvedilol is known to be an adrenoreceptor blocker and free radical scavenger, used in hypertension and cardiac failure. However, its therapeutic actions cannot be fully explained by these mechanisms. In these studies, we tested the hypothesis that carvedilol action is associated with the synthesis/release ...

journal_title：American journal of hypertension

authors： Afonso RA,Patarrao RS,Macedo MP,Carmo MM

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND:Various factors are implicated in the circadian pattern of cardiovascular vulnerability. The exact mechanisms involved in the peak incidence of cardiovascular events occurring during the early morning hours after awaking are not completely known. The purpose of our study was to investigate the circadian vari...

journal_title：American journal of hypertension

authors： Papaioannou TG,Karatzis EN,Papamichael CM,Karatzi KN,Zakopoulos NA,Lekakis JP,Mavrikakis M,Stefanadis C

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:C-reactive protein (CRP) predicts cardiovascular outcome. Oxidative stress is considered to be involved in endothelial alteration. We hypothesized that in essential hypertension (EH), oxidative stress, as measured by 8-iso-prostaglandin-F(2alpha) (8-iso-PGF(2alpha)), should be associated with increased CRP a...

journal_title：American journal of hypertension

authors： Cottone S,Mulè G,Nardi E,Vadalà A,Guarneri M,Briolotta C,Arsena R,Palermo A,Riccobene R,Cerasola G

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:The aim of this study was to clarify the response of endothelial connexins to hypertension and antihypertensive drugs. METHODS:Rats remained normotensive (group 1, N = 10) or were made hypertensive using N(omega)-nitro-L-arginine methyl ester (L-NAME) (groups 2 to 4, N = 10/group). Seven weeks later groups ...

journal_title：American journal of hypertension

authors： Yeh HI,Lee PY,Su CH,Tian TY,Ko YS,Tsai CH

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND:Sustained hypotension after an acute dynamic exercise bout is due primarily to peripheral vasodilation. We tested the hypothesis that adenosine-mediated vasodilation contributes to hypotension after exercise, by determining the effect of blocking its actions with caffeine. METHODS:Fourteen healthy middle-ag...

journal_title：American journal of hypertension

authors： Notarius CF,Morris BL,Floras JS

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND:Elevated blood pressure (BP) is a risk factor for cardiovascular disease (CVD), but it remains unclear which component-alone or in combination-is the best predictor. We sought to determine which BP parameters are important predictors of CVD death across a wide age range. METHODS:We used a prospective cohort...

journal_title：American journal of hypertension

authors： Bowman TS,Sesso HD,Gaziano JM

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Morning blood pressure (BP) surge seems to be a risk factor for cardiovascular events. Although physical activity after arising significantly affects morning BP surge, it has remained unclear whether morning BP surge after controlling for physical activity (morning BP reactivity) is associated with target or...

journal_title：American journal of hypertension

authors： Kaneda R,Kario K,Hoshide S,Umeda Y,Hoshide Y,Shimada K

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:B-type natriuretic peptide (BNP) increases the risk of death and cardiovascular events in patients without heart failure, even at BNP values within the "normal" range. The reasons for this are unclear. METHODS:We performed two separate studies (n = 33 and n = 129) on subjects with type 2 diabetes mellitus i...

journal_title：American journal of hypertension

authors： Dawson A,Davies JI,Morris AD,Struthers AD

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:Little is known about hypertension in the HIV-infected population. This study aimed to assess the prevalence of hypertension and related factors in HIV-infected patients. METHODS:In this prospective cross-sectional study, 710 HIV-infected patients (626 on combination antiretroviral therapy and 84 naive) man...

journal_title：American journal of hypertension

authors： Jericó C,Knobel H,Montero M,Sorli ML,Guelar A,Gimeno JL,Saballs P,López-Colomés JL,Pedro-Botet J

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:Renal tubulointerstitial infiltration of activated T cells and macrophages is invariably present and plays a role in elevation of arterial pressure in nearly all animal models of hypertension (HTN). The role, if any, of elevated renal arterial pressure in the pathogenesis of this inflammatory process is unce...

journal_title：American journal of hypertension

authors： Rodriguez-Iturbe B,Quiroz Y,Kim CH,Vaziri ND

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:A successful weight loss program is essential treatment for obesity-related diseases, but it is well known that the majority of individuals do not succeed in weight loss maintenance. The present study evaluates hormonal mechanisms and the relationship of beta2-adrenoceptor polymorphisms involved in individua...

journal_title：American journal of hypertension

authors： Masuo K,Katsuya T,Kawaguchi H,Fu Y,Rakugi H,Ogihara T,Tuck ML

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:Different methods of normalizing left ventricular (LV) mass for body size identify generally similar relative risks of adverse cardiovascular outcome but with variable prevalences of LV hypertrophy (H). Preliminary results from a population with high prevalence of obesity suggest that the population attribut...

journal_title：American journal of hypertension

authors： de Simone G,Devereux RB,Maggioni AP,Gorini M,de Divitiis O,Verdecchia P,MAVI (MAssa Ventricolare sinistra nell'Ipertensione) Study Group.

更新日期：2005-10-01 00:00:00

abstract：BACKGROUND:The aim of this study was to test the hypothesis that angiotensin converting enzyme inhibition or angiotensin II antagonism can counteract cardiac human vascular endothelial growth factor-A165 (phVEGF-A165) induced angiogenesis. METHODS:Mice were given a single intramyocardial injection of phVEGF-A165. Eith...

journal_title：American journal of hypertension

authors： Siddiqui AJ,Mansson-Broberg A,Gustafsson T,Grinnemo KH,Dellgren G,Hao X,Fischer H,Sylvén C

更新日期：2005-10-01 00:00:00

abstract：BACKGROUND:Activation of RhoA/Rho kinase (ROK) pathway by angiotensin II (Ang II) is involved in the pathophysiology of hypertension and remodeling. In Bartter's and Gitelman's syndrome (BS/GS), the short-term and long-term signaling of Ang II are blunted. The BS/GS have also reduced expression and response on Ang II c...

journal_title：American journal of hypertension

authors： Pagnin E,Semplicini A,Sartori M,Pessina AC,Calò LA

更新日期：2005-09-01 00:00:00

abstract：:Angiotensin II (Ang II) plays important roles in the development of cardiovascular diseases including hypertension, renal diseases, cardiac hypertrophy, congestive heart failure, and ischemic heart disease. Angiotensin II exerts classic hemodynamic and renal effects, but it is also a local biologically active mediator...

journal_title：American journal of hypertension

authors： Levy BI

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:Recent studies have shown that tamoxifen, which belongs to a group called selective estrogen receptor modulators (SERM), may exert protective effects against cardiovascular diseases and stroke in postmenopausal women. On the other hand, abnormalities in physical properties of the cell membranes may underlie ...

journal_title：American journal of hypertension

authors： Tsuda K,Nishio I

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND:Epidemiologic analysis of family data on blood pressure (BP) is often compromised by the effects of antihypertensive medications. A review of numerous clinical trials that investigated the effects of BP-lowering medications is summarized here. METHODS:Published clinical trials, including 137 clinical trials...

journal_title：American journal of hypertension

authors： Wu J,Kraja AT,Oberman A,Lewis CE,Ellison RC,Arnett DK,Heiss G,Lalouel JM,Turner ST,Hunt SC,Province MA,Rao DC

更新日期：2005-07-01 00:00:00

abstract：:Atherosclerosis is increasingly recognized as an inflammatory vascular disease, and high blood pressure (BP) has been suggested to exert a proinflammatory action. Whether plasma viscosity (PV), a major determinant of blood flow in microcirculation and a marker of systemic inflammation and cardiovascular risk, is incre...

journal_title：American journal of hypertension

authors： Ciuffetti G,Schillaci G,Lombardini R,Pirro M,Vaudo G,Mannarino E

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND:Recent reports suggesting that primary aldosteronism (PA) is more common than historically thought have often relied on use of the plasma aldosterone concentration (PAC) to plasma renin activity (PRA) ratio (ARR) to identify patients with PA. Prior determinations of the validity of the ARR had been generally...

journal_title：American journal of hypertension

authors： Nishizaka MK,Pratt-Ubunama M,Zaman MA,Cofield S,Calhoun DA

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND:This study analyzed whether hypertension induced by N(omega)-nitro-l-arginine methyl ester (L-NAME) is associated with dysregulation of the main antioxidant enzymes (superoxide dismutase [SOD], catalase, glutathione peroxidase [GPX], and glutathione reductase [GR]) and whether chronic administration of tempo...

journal_title：American journal of hypertension

authors： Sainz J,Wangensteen R,Rodríguez Gómez I,Moreno JM,Chamorro V,Osuna A,Bueno P,Vargas F

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND:Sleep apnea is being studied as a risk factor for hypertension. This observational chart review was conducted to determine the long-term effects of continuous positive airway pressure (CPAP) treatment on blood pressure (BP) in a sample of sleep apnea patients from urban and rural populations. METHODS:This s...

journal_title：American journal of hypertension

authors： Dhillon S,Chung SA,Fargher T,Huterer N,Shapiro CM

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:Postural change in systolic blood pressure (SBP) is prospectively associated with several disease outcomes including hypertension, stroke, and coronary heart disease. The objective of this study was to characterize further a possible quantitative trait locus on chromosome 18q21 influencing SBP response to a ...

journal_title：American journal of hypertension

authors： Pankow JS,Dunn DM,Hunt SC,Leppert MF,Miller MB,Rao DC,Heiss G,Oberman A,Lalouel JM,Weiss RB

更新日期：2005-05-01 00:00:00